2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-113315S
    3b-Hydroxy-5-cholenoic acid-d4 2770684-32-5 98%
    3b-Hydroxy-5-cholenoic acid-d4 is deuterium labeled 3b-Hydroxy-5-cholenoic acid (HY-113315). 3b-Hydroxy-5-cholenoic acid is a monohydroxy bile acid of endogenous origin.
    3b-Hydroxy-5-cholenoic acid-d4
  • HY-113334R
    Turanose (Standard) 547-25-1
    Turanose (Standard) is the analytical standard of Turanose. This product is intended for research and analytical applications. Turanose is an isomer of Sucrose that naturally exists in honey. Turanose has anti-inflammatory and regulates adipogenesis effect. Turanose has potential for obesity and related chronic diseases research[1][2].
    Turanose (Standard)
  • HY-113338A
    8-Hydroxyguanine hydrochloride 1246818-54-1 98%
    8-Hydroxyguanine hydrochloride is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine hydrochloride induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine hydrochloride is a marker of DNA oxidative damage.
    8-Hydroxyguanine hydrochloride
  • HY-113365R
    Cholestenone (Standard) 601-57-0
    Clebopride (malate) (Standard) is the analytical standard of Clebopride (malate). This product is intended for research and analytical applications. Clebopride malate is a dopamine antagonist used in the study of functional gastrointestinal disorders.
    Cholestenone (Standard)
  • HY-113367S
    Suberylglycine-d4 2469259-73-0 ≥99.0%
    Suberylglycine-d4 is the deuterium labeled Suberylglycine. Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid.
    Suberylglycine-d4
  • HY-113369S
    Cholesteryl arachidonate-d8 98%
    Cholesteryl arachidonate-d8 is deuterium labeled Cholesteryl arachidonate. Cholesteryl arachidonate is an endogenous metabolite.
    Cholesteryl arachidonate-d8
  • HY-113371R
    2-Methylcitric acid (Standard) 6061-96-7
    Omeprazole (sodium) (Standard) is the analytical standard of Omeprazole (sodium). This product is intended for research and analytical applications. Omeprazole sodium (H 16868 sodium), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole sodium shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM. Omeprazole sodium also inhibits growth of Gram-positive and Gram-negative bacteria. Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
    2-Methylcitric acid (Standard)
  • HY-113378R
    3-Hydroxybutyric acid (Standard) 300-85-6
    3-Hydroxybutyric acid (Standard) is the analytical standard of 3-Hydroxybutyric acid. This product is intended for research and analytical applications. 3-Hydroxybutyric acid (β-Hydroxybutyric acid) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid can modulate the properties of membrane lipids[1].
    3-Hydroxybutyric acid (Standard)
  • HY-113410R
    3-Methylglutaric acid (Standard) 626-51-7
    3-Methylglutaric acid (Standard) is the analytical standard of 3-Methylglutaric acid (HY-113410). This product is intended for research and analytical applications. 3-Methylglutaric acid is a non-selective inhibitor of mitochondrial function and Na+, K+-ATPase, with an inhibition rate of 30% on rat cortical synaptosomal Na+, K+-ATPase. 3-Methylglutaric acid can induce reactive oxygen species (ROS) generation, thereby causing oxidative damage and inhibiting mitochondrial redox potential and ion pump function of cell membranes. 3-Methylglutaric acid can be used to study the neuropathological mechanisms of metabolic diseases and the role of oxidative stress-mediated neuronal damage in neurodegeneration.
    3-Methylglutaric acid (Standard)
  • HY-113410S
    3-Methylglutaric acid-d4 1219798-68-1 98%
    3-Methylglutaric acid-d4 is the deuterium labeled 3-Methylglutaric acid (HY-113410). 3-Methylglutaric acid is a non-selective inhibitor of mitochondrial function and Na+, K+-ATPase, with an inhibition rate of 30% on rat cortical synaptosomal Na+, K+-ATPase. 3-Methylglutaric acid can induce reactive oxygen species (ROS) generation, thereby causing oxidative damage and inhibiting mitochondrial redox potential and ion pump function of cell membranes. 3-Methylglutaric acid can be used to study the neuropathological mechanisms of metabolic diseases and the role of oxidative stress-mediated neuronal damage in neurodegeneration.
    3-Methylglutaric acid-d4
  • HY-113413R
    Imidazoleacetic acid (Standard) 645-65-8
    Imidazoleacetic acid (Standard) is the analytical standard of Imidazoleacetic acid. This product is intended for research and analytical applications. Imidazoleacetic acid is an endogenous ligand that stimulates imidazole receptors.
    Imidazoleacetic acid (Standard)
  • HY-113451R
    3-Hydroxysebacic acid (Standard) 73141-46-5
    Propylparaben (sodium) (Standard) is the analytical standard of Propylparaben (sodium). This product is intended for research and analytical applications. Propylparaben sodium (Propyl parahydroxybenzoate) is an antimicrobial preservative which can be produced naturally by plants and bacteria. Propylparaben sodium is prevalently used in cosmetics, pharmaceuticals, and foods. Propylparaben sodium disrupts antral follicle growth and steroidogenic function by altering the cell-cycle, apoptosis, and steroidogenesis pathways. Propylparaben sodium also decreases sperm number and motile activity in rats.
    3-Hydroxysebacic acid (Standard)
  • HY-113474R
    3,4-Dihydroxymandelic acid (Standard) 775-01-9
    3,4-Dihydroxymandelic acid (Standard) is the analytical standard of 3,4-Dihydroxymandelic acid. This product is intended for research and analytical applications. 3,4-Dihydroxymandelic acid is a metabolite of norepinephrine.
    3,4-Dihydroxymandelic acid (Standard)
  • HY-113478R
    3β-Ursodeoxycholic acid (Standard) 78919-26-3
    3β-Ursodeoxycholic acid (Standard) is the analytical standard of 3β-Ursodeoxycholic acid. This product is intended for research and analytical applications. 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) is a bile acid. 3β-Ursodeoxycholic acid shows good tolerance and well intestinal absorption by oral adminstation. 3β-Ursodeoxycholic acid can be isomerized by intestinal and hepatic enzymes to yield UDCA.
    3β-Ursodeoxycholic acid (Standard)
  • HY-113486R
    Lathosterol (Standard) 80-99-9
    Lathosterol (Standard) is the analytical standard of Lathosterol (HY-113486). This product is intended for research and analytical applications. Lathosterol is a plant sterol and cholesterol-like molecule. Lathosterol increases antioxidant enzymes (such as SOD, CAT, and GSH) and decreases LDH. Lathosterol has a hepatoprotective effect on mice with acetaminophen (HY-66005)-induced liver injury[1].
    Lathosterol (Standard)
  • HY-113493R
    4-Pyridoxic acid (Standard) 82-82-6
    4-Pyridoxic acid (Standard) is the analytical standard of 4-Pyridoxic acid. This product is intended for research and analytical applications. 4-Pyridoxic acid is a catabolic product of vitamin B6 which is excreted in the urine.
    4-Pyridoxic acid (Standard)
  • HY-113801R
    N-(3-Oxooctanoyl)-DL-homoserine lactone (Standard) 106983-27-1
    4-Epitetracycline (hydrochloride) (Standard) is the analytical standard of 4-Epitetracycline (hydrochloride). This product is intended for research and analytical applications. 4-Epitetracycline hydrochloride is an epimer of Tetracycline (HY-A0107). Tetracycline can undergo epimerization in solution to 4-Epitetracycline hydrochloride, which shows a much lower antibiotic activity.
    N-(3-Oxooctanoyl)-DL-homoserine lactone (Standard)
  • HY-113906A
    (αR,8aS)-GSK1614343 1092476-84-0 99.40%
    (αR,8aS)-GSK1614343 is the isomer of GSK1614343 (HY-113906). GSK1614343 is the potent antagonist of growth hormone secretagogues type 1a (GHS1a) receptors.
    (αR,8aS)-GSK1614343
  • HY-113955A
    CP-346086 dihydrate 1262769-98-1 98%
    CP-346086 dihydrate is a potent and orally active microsomal triglyceride transfer protein (MTP) inhibitor, with an IC50 of 2.0 nM for human and rodent MTP. CP-346086 dihydrate can lower plasma cholesterol and triglycerides in vivo.
    CP-346086 dihydrate
  • HY-114060A
    (R)-CFMB 2182298-09-3 99.75%
    (R)-CFMB is the R-enantiomer of CFMB (HY-114060). CFMB is an agonist of FFAR2- and FFAR3-specific with an EC50 value of 0.8 μM target hFFAR2 and 0.2 μM target rFFAR2.
    (R)-CFMB
Cat. No. Product Name / Synonyms Application Reactivity